Post-exposure prophylaxis (PEP) known as post-exposure prevention, is any preventive medical treatment started after exposure to a pathogen to prevent the infection from occurring. Guidelines lack a substantive evidence base to guide advice. It is extremely unlikely that this will change, as randomized studies of different drug regimens for PEP are not feasible owing to the complexity of exposure, low event rate, and inability to ethically have a place group. Our practitioners will advise the use of various medications. The most common drugs prescribed for PEP are zidovudine, lamivudine, and nelfinavir.
The process of post prophylaxis treatments
In people who have been accidentally exposed to HIV through needle-stick inoculation or contamination of mucous membranes by secretions, it has been shown that administration of ARVs within 72 hours of exposure reduces the likelihood of HIV infection being transmitted. In this situation, ART needs to be continued for one month. The following guidelines should be followed in the event of accidental occupational exposure to material (i.e., blood, secretions, excretions) that may contain HIV. Occupational exposure to potentially infectious material may occur through an injury with a sharp object that has been used on a patient or through the contamination of mucous surfaces with patients' blood or secretions.
The following types of exposures should be considered for post-exposure prophylaxis; Needle-stick injury or injury with a sharp object used on a patient, mucosal exposure of the mouth or eyes by splashing fluids, broken skin exposure to a small volume of blood or secretions such as may occur with sexual abuse.
The exposure can be classified as high risk or low risk for HIV infection, as follows; low risk solid, such as surgical needle, superficial exposure on intact skin. Small volume (e.g., drops of blood) on mucous membranes or non-intact skin.
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Post-exposure prophylaxis (PEP) known as post-exposure prevention, is any preventive medical treatment started after exposure to a pathogen to prevent the infection from occurring. Guidelines lack a substantive evidence base to guide advice. It is extremely unlikely that this will change, as randomized studies of different drug regimens for PEP are not feasible owing to the complexity of exposure, low event rate, and inability to ethically have a place group. Our practitioners will advise the use of various medications. The most common drugs prescribed for PEP are zidovudine, lamivudine, and nelfinavir.